Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1141-5. doi: 10.1016/s0960-894x(03)00033-7.

Abstract

New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.

MeSH terms

  • Alkylation
  • Chemical Phenomena
  • Chemistry, Physical
  • Indicators and Reagents
  • Peptide Library
  • Pyridones / chemical synthesis*
  • Pyridones / pharmacology*
  • Receptors, Opioid, delta / chemistry
  • Receptors, Opioid, delta / metabolism
  • Receptors, Opioid, kappa / agonists*
  • Receptors, Opioid, kappa / chemistry
  • Receptors, Opioid, mu / chemistry
  • Receptors, Opioid, mu / metabolism
  • Solutions
  • Structure-Activity Relationship

Substances

  • Indicators and Reagents
  • Peptide Library
  • Pyridones
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • Solutions